Endocrine Abstracts

Introduction: Hyperaldosteronism can induce elevated parathyroid hormone (PTH) levels, presumably by increasing calciuria. Furthermore, PTH stimulates aldosterone secretion in vitro, and increases angiotensin–II-stimulated aldosterone release. In a patient with hyperaldosteronism and hyperparathyroidism, PTH receptors were detected in aldosteronoma tissue. We present three patients sent to an endocrinologist for treatment/follow-up of primary hyperparathyroidism,...

Introduction: Hyponatremia is common in the emergency room, albeit frequently overlooked. Our objective was to describe the characteristics of hyponatremia in a cohort of emergency room patients, and evaluate how hyponatremia was studied and followed up.Material and methods: We studied all 211 patients under 70 years-of-age who presented/developed non-translocational hyponatremia (serum sodium (SNa) <135 mmol/l) during the first 48 h of their stay at...

Introduction: The contrast agents iopanoic acid and ipodate are potent inhibitors of thyroid function, reducing type I deodinase T3 generation, inhibiting thyroid liberation of T4 and T3, and T3 receptor binding, with off-label use in hyperthyroid emergencies. However, since the interruption of iopanoic acid production this year, neither agent is currently available in Spain.Case report: A 34-year-old male was ...

Obesity is a disease very prevalent and often associated with morbidities and cardiovascular risk factors. We explore the relationship between the presence of obesity with cardiovascular risk factors more frequent and the presence of cardiovascular disease (CVD) after (ischemic heart disease, cerebrovascular disease, peripheral artery).Material and methods: A sample of 1491 individuals of both sexes, over 14 years, elected by random sampling three of the...

The metabolic syndrome (MS) is a pathological entity that carries a high cardiovascular risk, and whose risk factors may occur at an early age. No data are available in our area on the influence of age on the prevalence of MS.Objectives: To determine the prevalence of MS in our area, by age group and compare the frequency of occurrence of MS in young adults (<40 years) (J) and mature adults (>40 years) (M).Methods: Observat...

Background: Birth weight is a marker and predictor of metabolic diseases in adult life. Fetal growth depends on the availability of nutrients, in turn cross the placental barrier by means of special cells called syncytiotrophoblasts, which express specific transporters for each type of nutrient. Glucose, the main energetic substrate for fetal development, is transported via facilitated diffusion, through glucose transporter proteins (GLUTs). Several investigations have focused...

Introduction: Adrenal tumors are common tumors with a prevalence of around 3% in a population over the age of 50 years. In contrast, adrenocortical carcinoma (ACC) is a rare malignancy (incidence 1–2 per 1 million population) with a heterogeneous presentation and a variable but generally bad prognosis. Patients present with evidence of adrenal steroid hormone excess in approximately 60% of cases.Case report: A 49-year-old woman with symptoms of faci...

Background: The fetal insulin hypothesis proposes that low birth weight, insulin resistance, and decreased insulin secretion in adulthood are genetically mediated. Babies with low birth weight have higher morbidity and mortality risk in adulthood. However, this situation could also occur in children with adequate weight at birth with genetic risk factors. The polymorphisms rs11708067 in ADCY5 and rs7754840 in CDKAL1 have been associated with low birth weight,...

Introduction: Type 1 diabetes mellitus (T1DM) is considered, in general, a disease of children and young adults with normal body mass index (BMI), linked to a genetic susceptibility based on autoimmunity. However, we know that it can be diagnosed at any age and we must differentiate it from type 2 diabetes mellitus.Objetives: To investigate the phenotypic characteristics and the presence of specific autoimmunity in T1DM patients diagnosed in our hospital...

Introduction: New long-acting insulin analogues (insulin degludec –ID- and insulin glargine 300 U/ml –IG300-) have proved, in clinical trials, that improve metabolic control with lower hypoglycemia rate in T2D.Objective: To assess characteristics of T2D patients who were given ID and IG300 and to evaluate their effect on metabolic control, weight and insulin dose.Material and methods: We studied T2D patients whose treatme...